Lymphocyte-Specific Protein tyrosine Kinase (LCK) Peptide
LCK
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN979230
Aperçu rapide pour Lymphocyte-Specific Protein tyrosine Kinase (LCK) Peptide (ABIN979230)
Antigène
LCK
(Lymphocyte-Specific Protein tyrosine Kinase (LCK))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-LCK antibody (Catalog #: ARP54525_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))
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Sujet
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LCK is a member of the Src family of protein tyrosine kinases (PTKs). It is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules.This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.
Alias Symbols: YT16, p56lck, pp58lck, LSK
Protein Interaction Partner: CD8B,DNM2,HCVgp1,KHDRBS1,NFKBIA,ACP1,ADAM15,AXL,BCAR1,CBL,CCR5,CD2,CD247,CD28,CD38,CD3E,CD4,CD44,CD48,CD5,CD55,CD79A,CD79B,CD8A,CDC25C,CDC42,CSF2RB,CSF3R,CSK,CTLA4,CTNND2,DAPP1,DEF6,DLG1,DOK1,DOK2,DOK3,ESR1,EZR,FAS,FASLG,FCGR3A,GAB2,GRAP,HSP90AA1,IFNAR1,IL2RB,ITK,JAK3,KHDRBS1,KIR2DL3,KIT,LAT,LAX1,LCK,LCP2,LIME1,MAPK1,MAPK3,MED28,MS4A1,MUC1,NEDD9,NFKBIA,NOTCH1,NR3C1,PAG1,PAK2,PECAM1,PIK3CA,PIK3R1,PLCG1,PLCG2,PLD2,PRKACA,PRKCA,PRKCD,PRKCQ,PTK2,PTK2B,PTPN11,PTPN22,PTPN6,PTPRC,PTPRF,PTPRH,PXN,RAF1,RASA1,SH2B3,SH2D1A,SH2D2A,SH3BP2,SHC1,SIT1,SKAP1,SQSTM1,STAT1,STAT3,STAT5A,SYK,THY1,TRAT1,TRPV4,TUB,UNC119,VAV1,ZAP70,ADAM10,ADAM15,ARHGAP17,AXL,BCAR1,CBL,CD2,CD4,CD44,CD48,CTLA4,CTNND1,Cd3e,DLG1,FAS,FASLG,KHDRBS1,KIT,MS4A1,NEDD9,NOTCH1,NR2F2,PAG1,PECAM1,PI4KA,PIK3CA,PIK3R1,PRKCQ,PTK2B,PTPN6,PTPRC,PXN,RAF1,RASA1,SH2B3,SIT1,SKAP1,SQSTM1,SYK,THY1,TRAT1,TRPV4,UBE3A,UNC119,ZAP70
Protein Size: 509 -
Poids moléculaire
- 58 kDa
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ID gène
- 3932
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NCBI Accession
- NM_001042771, NP_001036236
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UniProt
- P06239
Antigène
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